RESUMO
Commentary on: Kaundal R, Bhatia P, Jain A, et al. Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia. Ann Hematol. 2020;99:57-63. Series Editor: Dr Teck Khong, DTB Associate Editor, Clinical Pharmacology, St George's, University of London, UK.
Assuntos
Anemia Ferropriva , Ferro , Humanos , Ferro/uso terapêutico , Anemia Ferropriva/tratamento farmacológico , Administração OralRESUMO
Commentary on: Heerspink HJL, Stefánsson BV, Correa-Rotter R, et al Dapagliflozin in patients with chronic kidney disease. N Engl J Med 2020;383:1436-46. Series Editor: Dr Teck Khong, DTB Associate Editor, Clinical Pharmacology, St George's, University of London, UK.
Assuntos
Compostos Benzidrílicos , Insuficiência Renal Crônica , Humanos , Compostos Benzidrílicos/uso terapêutico , Glucosídeos/uso terapêutico , Insuficiência Renal Crônica/tratamento farmacológicoRESUMO
Commentary on: Mackenzie IS, Rogers A, Poulter NR, et al Cardiovascular outcomes in adults with hypertension with evening vs morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial. Lancet 2022;400:1417-25.
Assuntos
Anti-Hipertensivos , Hipertensão , Adulto , Humanos , Pressão Sanguínea , Estudos de Tempo e Movimento , Estudos Prospectivos , Esquema de Medicação , Hipertensão/tratamento farmacológico , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
Commentary on: Anker SD, Butler J, Filippatos G, et al Empagliflozin in heart failure with a preserved ejection fraction. New England Journal of Medicine, 2021; 385:1451-61.
Assuntos
Insuficiência Cardíaca , Humanos , Insuficiência Cardíaca/tratamento farmacológico , Volume Sistólico , Compostos Benzidrílicos/uso terapêutico , Glucosídeos/uso terapêuticoRESUMO
Commentary on: Sheppard JP, Burt J, Lown M, et al Effect of antihypertensive medication reduction vs usual care on short-term blood pressure control in patients with hypertension aged 80 years and older: The OPTIMISE randomized clinical trial. JAMA 2020;323:2039-51.Series co-ordinator: Dr Teck Khong, DTB Associate Editor, Clinical Pharmacology, St George's, University of London, UK.
Assuntos
Anti-Hipertensivos , Desprescrições , Hipertensão , Idoso de 80 Anos ou mais , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea , Humanos , Hipertensão/tratamento farmacológico , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
Commentary on: Chow CK, Atkins ER, Hillis GS, et al Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial. Lancet 2021;398:1043-52. Series co-ordinator: Dr Teck Khong, DTB Associate Editor Clinical Pharmacology, St George's, University of London, UK.
Assuntos
Anti-Hipertensivos , Hipertensão , Anti-Hipertensivos/administração & dosagem , Ensaios Clínicos Fase III como Assunto , Quimioterapia Combinada , Humanos , Hipertensão/tratamento farmacológico , Irbesartana/administração & dosagem , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
Commentary on: Maron DJ, Hochman JS, Reynolds HR, et al Initial Invasive or Conservative Strategy for Stable Coronary Disease. N Engl J Med 2020;382:1395-1407.Series co-ordinator: Dr Teck Khong, DTB Associate Editor Clinical Pharmacology, St George's, University of London, UK.
Assuntos
Doença da Artéria Coronariana , Isquemia Miocárdica , Intervenção Coronária Percutânea , Humanos , Isquemia Miocárdica/terapiaRESUMO
Commentary on: Mehta SR, Wood DA, Storey RF, et al Complete Revascularization with Multivessel PCI for Myocardial Infarction. N Engl J Med 2019; 381:1411-21. Commentary by: Dr Emma Magavern and Dr Teck Khong Clinical Pharmacology, St George's, University of London, UK. Series Editor: Dr Teck Khong, DTB Associate Editor Clinical Pharmacology, St George's, University of London, UK.
Assuntos
Intervenção Coronária Percutânea , Infarto do Miocárdio com Supradesnível do Segmento ST , HumanosRESUMO
Commentary on: McMurray JJV, Solomon SD, Inzucchi SE, et al Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med 2019;381:1995-2008. Commentary by: Dr Joshua Au Yeunga, Clinical Pharmacology, St Thomas' Hospital, London, UK and Dr Teck Khong, Clinical Pharmacology, St George's, University of London, UK. Series Editor: Dr Teck Khong, DTB Associate Editor, Clinical Pharmacology, St George's, University of London, UK.
Assuntos
Compostos Benzidrílicos/uso terapêutico , Glucosídeos/uso terapêutico , Insuficiência Cardíaca/tratamento farmacológico , Insuficiência Cardíaca/epidemiologia , Hospitalização/estatística & dados numéricos , Idoso , Diabetes Mellitus/epidemiologia , Feminino , Insuficiência Cardíaca/mortalidade , Humanos , Nefropatias/epidemiologia , Masculino , Pessoa de Meia-Idade , Inibidores do Transportador 2 de Sódio-GlicoseRESUMO
Commentary on: Wiviott SD, Raz I, Bonaca MP, et al Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2019;380:347-57. Commentary by: Dr Emma Magavern and Dr Teck Khong Clinical Pharmacology, St George's, University of London, UK Series Editor: Dr Teck Khong, DTB Associate Editor Clinical Pharmacology, St George's, University of London, UK.
Assuntos
Doenças Cardiovasculares , Diabetes Mellitus Tipo 2 , Compostos Benzidrílicos , Glucosídeos , HumanosRESUMO
Commentary by: Dr James Kimpton and Dr Teck Khong Clinical Pharmacology, St George's, University of London, UKSeries Editor: Dr Teck Khong, DTB Associate Editor Clinical Pharmacology, St George's, University of London, UKCommentary on: Kraus WE, Bhapkar M, Huffman KM, et al 2 years of calorie restriction and cardiometabolic (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial. Lancet Diabetes Endocrinol 2019; 7: 673-83.
Assuntos
Restrição Calórica , Fatores de Risco Cardiometabólico , Humanos , Qualidade de VidaRESUMO
Commentary on: Zeng C, Dubreuil M, LaRochelle MR, et al Association of tramadol with all-cause mortality among patients with osteoarthritis. JAMA 2019;321:969-82 Commentary by: Dr Catrin Page and Dr Teck Khong Clinical Pharmacology, St George's, University of London, UK Series Editor: Dr Teck Khong, DTB Associate Editor Clinical Pharmacology, St George's, University of London, London, UK.
Assuntos
Osteoartrite , Tramadol , Humanos , LondresRESUMO
Commentary on: Narayan SW, Pearson SA, Litchfield M, et al Anticholinergic medicines use among older adults before and after initiating dementia medicines. BJCP 2019;85:1957-1963.Commentary by: Dr Christopher JD Threapleton and Dr Teck Khong, Clinical Pharmacology, St George's, University of London, UKSeries Editor: Dr Teck Khong, DTB Associate Editor, Clinical Pharmacology, St George's, University of London, London, UK.
Assuntos
Antagonistas Colinérgicos , Demência , Idoso , HumanosRESUMO
DTB commentaries provide an overview of, and commentary on, a clinical trial, systematic review or observational study.
